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  • Title: Ethanol-induced component of 45Ca2+ uptake in PC12 cells is sensitive to Ca2+ channel modulating drugs.
    Author: Greenberg DA, Carpenter CL, Messing RO.
    Journal: Brain Res; 1987 Apr 28; 410(1):143-6. PubMed ID: 2438011.
    Abstract:
    We compared the properties of depolarization-dependent 45Ca2+ uptake in PC12 cells grown with and without 200 mM ethanol for 6 days. Ethanol exposure increased 45Ca2+ uptake by 54%, but the ethanol-induced component of uptake retained properties of Ca2+ flux through voltage-dependent Ca2+ channels, including sensitivity to Ca2+ channel modulating drugs. Such drugs may therefore have a role in counteracting ionic events underlying ethanol dependence and withdrawal.
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