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Title: Conductance properties of GABA-activated chloride currents recorded from cultured hippocampal neurons. Author: Allen CN, Albuquerque EX. Journal: Brain Res; 1987 Apr 28; 410(1):159-63. PubMed ID: 2438013. Abstract: The conductance characteristics of gamma-aminobutyric acid-activated single channel currents from cultured hippocampal neurons were examined using patch clamp techniques. GABA-activated currents had amplitudes which were linearly correlated to the membrane potentials over a range of -80 to +70 mV and an open time and burst time of 2.2 and 4.3 ms, respectively. The conductance of the gamma-aminobutyric acid-activated channels was 19 pS. These data demonstrate that cultured hippocampal neurons have channel conductances which have characteristics different from those of adult neurons.[Abstract] [Full Text] [Related] [New Search]