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  • Title: Differentiation of an Abelson virus-transformed immature B precursor cell line under the expression of tyrosine kinase activity of v-abl oncogene product.
    Author: Maeda T, Owada MK, Sugiyama H, Miyake S, Tani Y, Ogawa H, Oka Y, Komori T, Soma T, Kishimoto S.
    Journal: Cell Differ; 1987 Apr; 20(4):263-9. PubMed ID: 2438051.
    Abstract:
    The expression of v-abl oncogene during the in vitro differentiation of an Abelson-virus-transformed immature B precursor cell line from immunoglobulin-null to intracytoplasmic mu-positive cells and further to intracytoplasmic gamma 2b-positive cells was examined. The results showed no significant alteration in the amounts and tyrosine kinase activity of v-abl oncogene product during differentiation, indicating that B cell differentiation processes are independent of v-abl functions.
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