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  • Title: Correlation of pachytene chromomeres and metaphase bands of human chromosomes, and distinctive properties of telomeric regions.
    Author: Ambros PF, Sumner AT.
    Journal: Cytogenet Cell Genet; 1987; 44(4):223-8. PubMed ID: 2438094.
    Abstract:
    By means of double staining with DAPI and chromomycin A3, we show that the chromomeres of human pachytene chromosomes are generally DAPI positive and chromomycin negative, like the G- or Q-bands of mitotic chromosomes. Thus we have demonstrated, using an objective technique not based on morphological comparisons, that chromomeres and G-bands are equivalent. However, terminal chromomeres and the ends of mitotic chromosomes, as well as a few other sites, are chromomycin positive and DAPI negative. The ends of human chromosomes appear, therefore, to contain a distinctive class of GC-rich DNA.
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