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  • Title: New routes towards reutericyclin analogues.
    Author: Jones RC, Bullous JP, Law CC, Elsegood MR.
    Journal: Chem Commun (Camb); 2014 Feb 14; 50(13):1588-90. PubMed ID: 24382380.
    Abstract:
    A range of N-acylpyrrolo[3,4-c]isoxazoles and derived N-acyltetramides has been prepared via a nitrile oxide dipolar cycloaddition approach, as analogues of the acyltetramic acid metabolite reutericyclin, of interest for its antibiotic potential against Gram-positive bacteria including hospital-acquired infections of resistant Clostridium difficile.
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