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  • Title: Effect of calcium antagonist and agonist on free fatty acid liberation in the ischemic brain of rats.
    Author: Kidooka M, Matsuda M, Handa J.
    Journal: Surg Neurol; 1987 Jul; 28(1):41-5. PubMed ID: 2438789.
    Abstract:
    Using an experimental model of global ischemia of the brain in rats, we have shown that a Ca2+ antagonist nicardipine attenuates, and a Ca2+ agonist YC-170 accelerates, the liberation of free fatty acids in the ischemic whole brain. The effects of YC-170 were negated by the previous administration of an adequate dose of nicardipine. This is the first report on the action of a Ca2+ agonist on the metabolism of the brain, and the results seem to provide supportive evidence for the role of Ca2+ in ischemic injury of the brain.
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