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  • Title: Hippo tips the TGF-β scale in favor of pluripotency.
    Author: Mullen AC.
    Journal: Cell Stem Cell; 2014 Jan 02; 14(1):6-8. PubMed ID: 24388171.
    Abstract:
    How TGF-β signaling switches from enforcing pluripotency to promoting mesendodermal differentiation remains an open question. Recently in Cell Reports, Beyer et al. demonstrated that Hippo signaling components recruit the NuRD complex to repress expression of key genes targeted by TGF-β and thus determine whether TGF-β signaling will favor pluripotency or differentiation.
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