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  • Title: Effect of praziquantel on the cardiotonic action of cardiac glycosides.
    Author: Khayyal MT, Saleh S, Schlieper P, Tawfik H.
    Journal: Arch Int Pharmacodyn Ther; 1987 Mar; 286(1):85-96. PubMed ID: 2439032.
    Abstract:
    The effect of praziquantel on isolated left guinea-pig atria has been studied. Praziquantel caused a concentration-dependent increase in the force of contraction of the isolated left atria, an effect which may be due to an increase in Ca++ fluxes. Praziquantel antagonized the cardiotonic effect of cardiac glycosides on guinea-pig atria. This antagonism is neither due to an alteration of Ca++ concentration in the cell, nor to a direct action on Na+, K+-ATPase, nor to inhibition of the binding of cardiac glycosides to heart tissue. This interaction may involve an enhancement of K+ fluxes in cardiac cells under the influence of praziquantel.
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