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  • Title: Dihydropyridine chirality at the chromaffin cell calcium channel.
    Author: Fonteriz RI, Gandia L, Lopez MG, Artalejo CR, García AG.
    Journal: Brain Res; 1987 Apr 07; 408(1-2):359-62. PubMed ID: 2439171.
    Abstract:
    The racemic mixture of the dihydropyridine PN200-110 (Sandoz) inhibits K+-evoked catecholamine release from cat adrenal glands with an IC50 of 4.1 nM; IC50's for (+)- and (-)-PN200-110 were 0.84 and 45.8 nM, respectively. While the (+)-enantiomer of the dihydropyridine Sandoz 202-791 potentiated secretion (EC50 = 100 nM), the (-)-enantiomer behaved as a potent inhibitor (IC50 = 10 nM). Since K+-evoked 45Ca-uptake was also potently inhibited by (+)-PN200-110, it seems that the chromaffin cell dihydropyridine receptor is associated to the voltage-dependent Ca-channel and that it exhibits an exquisite stereoselectivity.
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