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  • Title: Loss of multi-epitope specificity in memory CD4(+) T cell responses to B. pertussis with age.
    Author: Han WG, van Twillert I, Poelen MC, Helm K, van de Kassteele J, Verheij TJ, Versteegh FG, Boog CJ, van Els CA.
    Journal: PLoS One; 2013; 8(12):e83583. PubMed ID: 24391789.
    Abstract:
    Pertussis is still occurring in highly vaccinated populations, affecting individuals of all ages. Long-lived Th1 CD4(+) T cells are essential for protective immunity against pertussis. For better understanding of the limited immunological memory to Bordetella pertussis, we used a panel of Pertactin and Pertussis toxin specific peptides to interrogate CD4(+) T cell responses at the epitope level in a unique cohort of symptomatic pertussis patients of different ages, at various time intervals after infection. Our study showed that pertussis epitope-specific T cell responses contained Th1 and Th2 components irrespective of the epitope studied, time after infection, or age. In contrast, the breadth of the pertussis-directed CD4(+) T cell response seemed dependent on age and closeness to infection. Multi-epitope specificity long-term after infection was lost in older age groups. Detailed knowledge on pertussis specific immune mechanisms and their insufficiencies is important for understanding resurgence of pertussis in highly vaccinated populations.
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