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  • Title: Balgacyclamides, antiplasmodial heterocyclic peptides from Microcystis aeruguinosa EAWAG 251.
    Author: Portmann C, Sieber S, Wirthensohn S, Blom JF, Da Silva L, Baudat E, Kaiser M, Brun R, Gademann K.
    Journal: J Nat Prod; 2014 Mar 28; 77(3):557-62. PubMed ID: 24392715.
    Abstract:
    The isolation and structural characterization of three new heterocyclic and macrocyclic peptides, balgacyclamides A-C, from Microcystis aeruginosa EAWAG 251 are reported. The constitutions were determined by 2D-NMR methods and mass spectrometry, and the configurations were assigned after ozonolysis and hydrolysis by HPLC-MS methods using Marfey's method as well as GC-MS using authentic standards. Balgacyclamides A and B were active against Plasmodium falciparum K1 in the low micromolar range, while displaying low toxicity to rat myoblasts.
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