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  • Title: Brain-stem auditory evoked potentials in the alligator. Effects of temperature and hypoxia.
    Author: Strain GM, Tucker TA, Graham MC, O'Malley NA.
    Journal: Electroencephalogr Clin Neurophysiol; 1987 Jul; 67(1):68-76. PubMed ID: 2439283.
    Abstract:
    Brain-stem auditory evoked potentials (BAEPs) were recorded from young alligators (Alligator mississippiensis), and the effects of hypothermia, hyperthermia and hypoxia on the wave forms were determined. The wave form shape was similar to the human BAEP, although extra waves were routinely seen. The responses were highly repeatable and varied in a predictable manner as a function of stimulus frequency, polarity, intensity, and body temperature. Rarefaction clicks produced longer wave form latencies than condensation clicks. BAEPs were present over the entire temperature range studied (0-36 degrees C). In contrast, mammalian BAEPs disappear over the temperature range of 20-27 degrees C, and seizures occur at 20-21 degrees C. At temperatures below 20 degrees C, the alligator BAEP peak amplitudes decreased with decreased temperature, but latencies only decreased slightly. At temperatures above 20 degrees C the peak amplitudes increased, and the latencies decreased with temperature. Peak I was largely unaffected by temperature change, while peaks IIIa and V increased 0.015 and 0.018 msec/degree C, respectively, at temperatures above 24 degrees C. Transient brain hypoxia, achieved by inverting the alligator, produced a progressive decrease in BAEP waves to an isoelectric amplitude without greatly altered latencies. The reverse sequence of changes was seen during recovery. Postural effects on blood flow were documented in two alligators with implanted flow probes. Carotid artery blood flow decreased 43% with body inversion, in both anesthetized and unanesthetized alligators, but no sequelae from the hypoxia could be detected. Metabolic differences between mammals and the alligator may account for the alligator's resistance to hypothermia, hyperthermia and hypoxia.
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