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  • Title: Lithium ion reversibly inhibits inducer-stimulated adipose conversion of 3T3-L1 cells.
    Author: Aratani Y, Sugimoto E, Kitagawa Y.
    Journal: FEBS Lett; 1987 Jun 22; 218(1):47-51. PubMed ID: 2439378.
    Abstract:
    Adipose conversion of 3T3-L1 cells by inducers (dexamethasone, 1-methyl-3-isobutylxanthine and insulin) was inhibited by LiCl at concentrations from 2 to 20 mM. The effect of LiCl was reversible and the inhibited cells were converted to adipocytes when stimulated after the removal of LiCl. Inhibition by LiCl of adipose conversion was accompanied with a blockage of the enhanced [3H]thymidine incorporation and cellular proliferation that occurred before the adipocyte phenotype was expressed. Of the cations tested, only Li+ had these effects.
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