These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Indoleamine 2, 3-dioxygenase activity for breast cancer patients with recurrence 5 or more years after surgery].
    Author: Sakurai K, Fujisaki S, Nagashima S, Maeda T, Tomita R, Suzuki S, Hara Y, Enomoto K, Amano S.
    Journal: Gan To Kagaku Ryoho; 2013 Nov; 40(12):1590-2. PubMed ID: 24393858.
    Abstract:
    We evaluated the significance of indoleamine 2, 3-dioxygenase( IDO) in breast cancer patients with recurrence 5 or more years after surgery. IDO activity can be measured by the tryptophan (Trp)/kynurenine (Kyn) ratio. Trp and Kyn were measured by high-performance liquid chromatography( HPLC). We encountered 32 patients in whom breast cancer recurred 5 or more years after surgery. The mean age of the patients was 56.8 years. The mean duration of years since the initial treatment for breast cancer was 9.3±3.8 years. The rate of hormone receptor positivity was 93.8%. Twelve patients were suitable for locoregional therapy and the remaining 20 patients required chemotherapy. The patients suitable for locoregional therapy had a better prognosis than those who required chemotherapy. The correlation of the Trp/Kyn ratio between these 2 groups (locoregional therapy group and chemotherapy group) was studied. The Trp/Kyn ratio was higher in patients suitable for locoregional therapy than in those who received chemotherapy. The prognosis was better in patients with a high Trp/Kyn ratio than in those with a low Trp/Kyn ratio. These results suggest that determining the Trp/Kyn ratio was useful in the prognosis of patients with breast cancer that recurred 5 or more years after surgery.
    [Abstract] [Full Text] [Related] [New Search]