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  • Title: Investigation of the interaction between five alkaloids and human hemoglobin by fluorescence spectroscopy and molecular modeling.
    Author: He W, Dou H, Li Z, Wang X, Wang L, Wang R, Chang J.
    Journal: Spectrochim Acta A Mol Biomol Spectrosc; 2014 Apr 05; 123():176-86. PubMed ID: 24394533.
    Abstract:
    This work studied the interaction of human hemoglobin (HHb) with aminophylline, acefylline, caffeine, theophylline and diprophylline systematically by UV-vis absorption spectroscopy and fluorescence spectroscopy in combination with molecular modeling. Five alkaloids caused the fluorescence quenching of HHb by the formation of alkaloids-HHb complex. The binding constants and thermodynamic parameters were obtained. The hydrophobic and electrostatic interactions were the predominant intermolecular forces to stabilize these complexes. Results of thermodynamic analysis and molecular modeling showed that aminophylline was the strongest quencher and diprophylline was the weakest quencher.
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