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  • Title: Dendrotoxin blocks potassium channels and slows sodium inactivation in Myxicola giant axons.
    Author: Schauf CL.
    Journal: J Pharmacol Exp Ther; 1987 Jun; 241(3):793-6. PubMed ID: 2439682.
    Abstract:
    Dendrotoxin (DTX) is known to partially block delayed rectifier K+ channels and enhance neurotransmitter release, but no effects on Na+ channels have been reported. In voltage-clamped Myxicola axons DTX affected both the K+ and Na+ conductances. DTX blocked completely Myxicola K+ channels with a KD of 150 nM and induced slow K+ inactivation. DTX doubled the time constants for inactivation of conducting Na+ channels and gating charge immobilization without altering Na+ activation or the voltage- and time-dependent fast and slow Na+ inactivation induced by depolarizing prepulses. A selective effect on open Na+ channel inactivation provides additional evidence for kinetic models in which resting Na+ channels need not open before being inactivated.
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