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  • Title: Enhanced poly(γ-glutamic acid) fermentation by Bacillus subtilis NX-2 immobilized in an aerobic plant fibrous-bed bioreactor.
    Author: Xu Z, Feng X, Zhang D, Tang B, Lei P, Liang J, Xu H.
    Journal: Bioresour Technol; 2014 Mar; 155():8-14. PubMed ID: 24398186.
    Abstract:
    To enhance poly(γ-glutamic acid) (PGA) production, a novel aerobic plant fibrous-bed bioreactor (APFB) was constructed for immobilized fermentation. Based on the analysis of the kinetics of immobilized-cell fermentation using the APFB and conventional free-cell fermentation, immobilized-cell fermentation exhibited more efficient PGA production. Furthermore, repeated fed-batch cultures for PGA production were conducted to evaluate the stability of the APFB system. Average final PGA concentration and productivity of 71.21±0.83g/L and 1.246±0.008g/L/h were respectively achieved by cells immobilized in bagasse during APFB, which was reused eight times over a period of 457±18h. Analysis of the membrane phospholipids and the key enzyme activities indicated that APFB-adapted cells had better productivity than original cells. Thus, this study demonstrated the significant potential of the APFB culture system in future industrial applications.
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