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  • Title: [Purification of a soluble tetrodotoxin-sensitive protein from the cytoplasmic fraction of bovine brain tissue].
    Author: Malysheva MK, Lishko VK, Zhukareva VA, Lysenko VV, Tret'iakov LA.
    Journal: Neirofiziologiia; 1987; 19(2):202-9. PubMed ID: 2439928.
    Abstract:
    Highly purified protein inducing tetrodotoxin-dependent Na fluxes in liposomal membrane was obtained from the cytoplasmic fraction of the bovine brain. The protein was purified by anion-exchange chromatography on DEAE-Servacell and wheat germ agglutinin sepharose (WGA) followed by gel filtration on sepharose 4B. It is a high-molecular weight acidic glycoprotein; during denaturation under reducing conditions it forms 55 kD subunits. It is suggested that the tetrodotoxin-sensitive protein could be a soluble intracellular precursor of the voltage-dependent sodium channels.
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