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  • Title: High-resolution reduced field of view diffusion tensor imaging using spatially selective RF pulses.
    Author: Gaggl W, Jesmanowicz A, Prost RW.
    Journal: Magn Reson Med; 2014 Dec; 72(6):1668-79. PubMed ID: 24399609.
    Abstract:
    PURPOSE: Diffusion tensor imaging (DTI) plays a vital role in identifying white matter fiber bundles. Achievable imaging resolution and imaging time demands remain the major challenges in detecting small fiber bundles with current clinical DTI sequences. METHODS: A novel reduced field of view ultra-high-resolution DTI technique named eZOOM (elliptically refocused zonally oblique multislice) was developed. A small circular disk was imaged using spatially selective radiofrequency (RF) pulses, reducing the imaging matrix size. The frequency profile of the spectral-spatial refocusing RF pulse provided intrinsic fat suppression, eliminating the need for fat saturation pulses. RESULTS: Multislice DTI at a resolution of 0.35 × 0.35 mm in a celery fiber phantom was successfully performed by scanning an 8-cm field of view at 3T. An adequate diffusion-to-noise ratio (DNR >20) was achieved for a 25-min acquisition using a direct-sampling RF receiver. Human subjects (n = 7) were scanned at resolutions of 0.47 × 0.47 mm having a DNR <20 within a 75-min scanning time, requiring further enhancements to increase the signal-to-noise ratio. CONCLUSIONS: The new eZOOM-DTI method offers multislice DTI at ultra-high imaging resolutions substantially exceeding those available with current echo-planar DTI techniques. Parallel and fast spin echo methods can be combined with eZOOM to improve SNR and DNR in humans.
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