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  • Title: [Flagellate dermatitis after bleomycin chemotherapy in a patient with malignant germ cell tumor].
    Author: Schummer C, Winkler Y, Tittelbach J, Grimm MO, Elsner P.
    Journal: Dtsch Med Wochenschr; 2014 Jan; 139(3):84-6. PubMed ID: 24399654.
    Abstract:
    HISTORY AND CLINICAL FINDINGS: A 49-year-old patient with malignant germ cell tumor within the first cycle PEB (platinum [P], etoposid [E] and bleomycin [B]) presented with an itchy linear papular erythema with discrete vesicles. The rash had appeared three days ago i. e. four days after the second application of bleomycin. INVESTIGATIONS: Visual diagnosis of a flagellate dermatitis. TREATMENT AND CLINICAL COURSE: Primary treatment consisted of systemic antihistamines, local and systemic application of steroids. Bleomycin treatment was stopped and substituted by ifosfamide. CONCLUSION: Flagellate dermatitis occurs with an incidence up to 66 % after bleomycin treatment. There is no association between bleomycin dose and incidence or severity of the lesions. Flagellate dermatitis is a self-limiting condition but hyperpigmentation may persist. Similar lesions may occur with bendamustine and docetaxel, the intake of insufficiently cooked shiitake mushrooms as well as in dermatomyositis and Still's syndrome.
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