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  • Title: A highly sensitive immunoassay using antibody-conjugated spherical mesoporous silica with immobilized enzymes.
    Author: Eum JY, Hwang SY, Ju Y, Shim JM, Piao Y, Lee J, Kim HS, Kim J.
    Journal: Chem Commun (Camb); 2014 Apr 07; 50(27):3546-8. PubMed ID: 24402353.
    Abstract:
    A highly sensitive immunoassay was developed by using antibody-conjugated spherical mesoporous silica with immobilized enzymes. The higher ratio of enzyme/antibody than conventional ELISA improved both the sensitivity and dynamic range. Especially, the use of spherical mesoporous silica could achieve a limit of detection (LOD) with a sensitivity that is 20 times more than that of ELISA using amorphous silica.
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