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  • Title: On the mechanism of dextran-induced histamine secretion from rat peritoneal mast cells.
    Author: Thompson HL, Leoutsakos A, Pearce FL.
    Journal: Agents Actions; 1987 Apr; 20(3-4):169-71. PubMed ID: 2440262.
    Abstract:
    The mechanism of histamine release induced from isolated rat peritoneal mast cells by clinical dextran was examined in detail. The putative involvement of cell-fixed IgE antibodies in the process was discounted by a number of experimental approaches. Instead, the characteristics of the release were found to be consistent with the interaction of the polysaccharide with specific glucoreceptors on the mast cell membrane.
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