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  • Title: Forskolin-insensitive adenylate cyclase in cultured cells of Choristoneura fumiferana (Insecta).
    Author: Gole JW, Orr GL, Downer RG.
    Journal: Biochem Biophys Res Commun; 1987 Jun 30; 145(3):1192-7. PubMed ID: 2440427.
    Abstract:
    Adenylate cyclase from a spruce budworm cell line, IBRI-Cfl, is activated by octopamine (Ka = 50 microM), guanine nucleotides and sodium fluoride but not by forskolin. In addition, forskolin does not potentiate the octopamine-sensitive response. To our knowledge, this is the first published report of a hormone-sensitive adenylate cyclase, with a functional guanine nucleotide regulatory protein, that is insensitive to forskolin both in intact cells and washed membrane preparations.
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