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  • Title: Temperature-dependence of cytotoxicity of several genotoxicants in Chinese hamster V79 cells: bleomycin, paraquat, and some N-alkyl-N-nitrosoureas.
    Author: Suzuki T, Kohda K, Kawazoe Y.
    Journal: Biochem Biophys Res Commun; 1987 Jul 15; 146(1):67-72. PubMed ID: 2440435.
    Abstract:
    Chinese hamster V79 cultured cells were treated with bleomycin (BLM), paraquat (PQ), N-methyl-N-nitrosourea (MNU), and ACNU (an anti-cancer agent) at 30-43 degrees C. The survival fractions normalized by those released from heat-death were plotted vs. the integrated doses of the chemical. Arrhenius analysis of the cell inactivation by the chemical was made. The results revealed that BLM and PQ exerted synergistic cytotoxicity with hyperthermia, whereas MNU and ACNU exerted temperature-dependent cytotoxicities obeying the Arrhenius law.
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