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  • Title: [Effect of the carcinogenic metabolites of aromatic amino acids on oxidative processes in lipids in vitro and in vivo].
    Author: Levchuk AA, Pal'mina NP, Raushenbakh MO.
    Journal: Biull Eksp Biol Med; 1987 Jul; 104(7):77-9. PubMed ID: 2441774.
    Abstract:
    A comparative study of the effect produced by endogenous carcinogens (p-hydroxyphenyllactic and 5-methoxyindole-3-acetic acids) and their non-cancerogenic analogues on lipid peroxidation in vitro and in vivo was performed. It has been found that cancerogenic tyrosine and serotonin metabolites, unlike their non-cancerogenic analogues, increase lipid peroxidation in vitro. In vivo, cancerogenic tyrosine metabolite--p-hydroxyphenyllactic acid--is capable both of increasing and decreasing antioxidative lipid activity in the animal liver.
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