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Title: Molecular genetics of the VDAC ion channel: structural model and sequence analysis. Author: Forte M, Guy HR, Mannella CA. Journal: J Bioenerg Biomembr; 1987 Aug; 19(4):341-50. PubMed ID: 2442148. Abstract: The voltage-dependent anion-selective channel of the outer mitochondrial membrane provides a unique system in which to study the molecular basis of voltage gating of ion flow. We have cloned and sequenced a cDNA coding for this protein in yeast. From the derived amino acid sequence, we have generated a preliminary model for the secondary structure of the protein which suggests that the protein forms a "beta-barrel" type structure. Comparison of the VDAC amino acid sequence with that of the bacterial porins has indicated that the two classes of molecules appear to be unrelated.[Abstract] [Full Text] [Related] [New Search]