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  • Title: Trichodermone, a spiro-cytochalasan with a tetracyclic nucleus (7/5/6/5) skeleton from the plant endophytic fungus Trichoderma gamsii.
    Author: Ding G, Wang H, Li L, Song B, Chen H, Zhang H, Liu X, Zou Z.
    Journal: J Nat Prod; 2014 Jan 24; 77(1):164-7. PubMed ID: 24422592.
    Abstract:
    Trichodermone (1), the first spiro-cytochalasan with an unprecedented tetracyclic nucleus (7/5/6/5), together with its possible biosynthetic precursor aspochalasin D (2), was isolated from the endophytic fungus Trichoderma gamsii. Compound 2 displayed moderate inhibitory activity against HeLa cells with an IC50 value of 5.72 μM.
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