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  • Title: [Effect of measured chemical sympathectomy on the dynamics of the chromatin functional indices of rat sympathetic neurocytes during their differentiation].
    Author: Chuchkova NN, Grigor'eva AV, Iarygin VN.
    Journal: Tsitologiia; 1987 Jun; 29(6):662-70. PubMed ID: 2442868.
    Abstract:
    Differences have been found between age-related shifts of DNA template activity of sympathetic neuron chromatin of normal and guanethidine-desympathized rats. The mean level of DNA template activity in mature neurons was the higher the heavier the desympathization of rat. In the ganglia of guanethidine-treated rats a subpopulation of neurocytes was revealed with an unusually high nucleolar-to-nucleoplasmic label ratio, never observed in control rats. The maturational disturbances in the course of alterations in histones visualized by ammoniacal silver, as well as shifts in the percentage of specifically stained nuclei are proportional to the level of desympathization. These changes in histones can be interpreted as a preliminary acceleration and aging of guanethidine-treated rat ganglia which are proportional to the number of destructed cells.
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