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  • Title: [Can changes in the gonadotropin response in androgen insensitivity syndrome be detected with the GnRH test following gonadectomy and steroid administration?].
    Author: Scholz B, Wodrig W, Göretzlehner G, Weber A.
    Journal: Zentralbl Gynakol; 1987; 109(12):777-82. PubMed ID: 2442922.
    Abstract:
    Information about the reaction of the hypothalamic pituitary axis by Gn-Rh-stimulation dependent from gonadectomy and steroid substitution in 3 patients with androgen insensitivity syndrome. The test was done before and after gonadectomy, under receipt of within the intake of a sequential hormonal contraceptive (Sequenz-Ovosiston) in the 16th cycle and after a pill free interval of 3 months, LH and FSH were estimated with a RIA-method. The LH-base-concentration is independent from the moment of the gonadectomy normogonadotrop and indicate after Gn-Rh-stimulation a regular LH-answer. The FSH-reaction is clearly dependent from the moment of gonadectomy. Not the gonadectomy but the steroid substitution over a long time is decisive about the reaction of the adenohypophysis. Information about the reaction of the hypothalamic-pituitary axis by Gn-Rh-stimulation dependent on gonadectomy and steroid substitution in 3 patients with androgen insensitivity syndrome is provided. Testing was done both before and after gonadectomy, after receiving the sequential contraceptive Ovosiston during the 16th cycle, and after a pill-free interval of 3 months. LH and FSH were estimated with a RIA method. The LH-base-concentration is independent of the moment of gonadectomy; the FSH reaction is clearly dependent on this occurrence. Steroid substitution was the decisive component in the reaction of the adenohypophysis. (author's modified)
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