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  • Title: [Renal sympathetic denervation in treatment-resistant hypertension].
    Author: Sørensen H, Fadl Elmula FE, Kjeldsen SE, Brekke M, Gjønnæss E, Hjørnholm U, Kjær VN, Rostrup M, Fossum E, Os I, Stenehjem A, Høieggen A, Hoffmann P.
    Journal: Tidsskr Nor Laegeforen; 2014 Jan 14; 134(1):32-6. PubMed ID: 24429753.
    Abstract:
    BACKGROUND: Renal denervation (RDN) has been introduced as a potential new treatment for patients with treatment-resistant hypertension, defined as a blood pressure above 140/90 mm Hg despite treatment with at least three antihypertensive drugs. We present an overview of this type of treatment, describe the method and discuss its possible future uses. METHOD: The review is based on a discretionary selection of relevant articles from our archive, our own experience and a literature search in PubMed. RESULTS: The use of RDN for treatment-resistant hypertension is based on a single randomised study with a total of 104 patients, in which the intervention group experienced a fall in blood pressure of 32/12 mm Hg, while blood pressure in the control group remained unchanged. More than 16,000 patients, particularly in Germany, have been treated on this basis. In the USA, data from a larger randomised study (n = 530) that includes sham surgery are awaited before any decision is made on whether to approve the method for use. INTERPRETATION: Before RDN can become recommended treatment in Norway, more evidence is required that the method lowers blood pressure, and that this reduces morbidity and mortality.
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