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  • Title: [Season fluctuations of carbamazepine and valproate concentration in patients with epilepsy].
    Author: Avakian GN, Oleĭnikova OM, Lagutin IuV, Khromykh EA, Bogomazova MA, Delger AB, Avakian GG.
    Journal: Zh Nevrol Psikhiatr Im S S Korsakova; 2013; 113(11):34-9. PubMed ID: 24429946.
    Abstract:
    We studied 107 patients with epilepsy who received monotherapy with valproic acid drugs (58) and carbamazepine (49). The seasonal distribution of number and severity of seizures assessed with the NHS3 scale in dependence of Cmin and Cmax content of antiepileptic drugs carbamazepine and valproates in the serum of patients was estimated. There was a significant increase in the number of seizures and their severity in the cycle spring>autumn>summer>winter. The serum content of carbamazepine and valproates was significantly lower in spring compared to autumn.
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