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  • Title: Adriamycin-induced histamine release from rat peritoneal mast cells: role of free radicals.
    Author: Decorti G, Klugmann FB, Candussio L, Baldini L.
    Journal: Anticancer Res; 1987; 7(3 Pt B):497-9. PubMed ID: 2443072.
    Abstract:
    The effect of pretreatment with various concentrations of catalase, superoxide-dismutase, D-mannitol, alpha-tocopherol, n-acetylcysteine and reduced glutathione on the release of histamine induced by adriamycin (100 micrograms/ml) on rat peritoneal mast cells was studied. Adriamycin caused an important histamine release in vitro which was not affected by pretreatment with the tested substances. Only n-acetylcysteine, at a very high concentration (1 X 10(-1) M) significantly limited this release. The substance was also active in inhibiting the release induced by a classic mast cell secretagogue, compound 48/80.
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