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  • Title: A nuclear factor which interacts with an AT-cluster in the first intron of rat alpha 2-macroglobulin gene.
    Author: Ito T, Sakaki Y.
    Journal: Biochem Biophys Res Commun; 1987 Sep 15; 147(2):824-30. PubMed ID: 2443139.
    Abstract:
    We have identified a nuclear protein which binds specifically to the first intron of rat alpha 2-macroglobulin gene. The protein became insoluble at low salt concentration retaining the binding specificity. Its molecular weight was estimated to be 22 kilodalton by a protein blotting procedure. The binding site of the protein determined by DNase I footprinting was an AT-strech which shared 80% homology with the cleavage consensus of Drosophila topoisomerase II.
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