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  • Title: [Analgesic properties of morpholinoethylimidazobenzimidazole derivative RU-1205].
    Author: Spasov AA, Grechko OIu, Shtareva DM, Anisimova VA.
    Journal: Eksp Klin Farmakol; 2013; 76(9):15-8. PubMed ID: 24432563.
    Abstract:
    We have studied the analgesic activity of a morpholinoethylimidazobenzimidazole derivative (RU-1205) in comparison to butorphanol. It is established that the test compound exhibits a pronounced analgesic activity, which exceeded that ofbutorphanol six times in the hot-plate test and was comparable to the reference drug effect in the tail-flick and acetic acid-induced writhing tests. It is established that the analgesic action of RU-1205 is based on the kappa-opioidergic mechanism.
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