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  • Title: Comparison of molecular properties of the voltage-sensitive Ca2+ channel from longitudinal smooth muscle of rabbit ileum with the channel purified from transverse tubules of rabbit skeletal muscle.
    Author: Ice KS, Takahashi M, Curtis BM, Catterall WA.
    Journal: Circ Res; 1987 Oct; 61(4 Pt 2):I24-9. PubMed ID: 2443272.
    Abstract:
    Dihydropyridine-sensitive calcium channels in membrane preparations from the longitudinal smooth muscle of rabbit ileum bound [3H]PN 200-110 with KD = 0.42 nM and Bmax = 265 fmol/mg. Calcium channels were labelled with [3H]PN 200-110 and solubilized with digitonin. The detergent-solubilized calcium channel had a sedimentation coefficient of 20.9 S in close agreement with the value of 20 S determined for the skeletal muscle calcium channel. Antibodies against the alpha-subunits of the skeletal muscle calcium channel specifically precipitated the calcium channel from smooth muscle. Our results suggest that the calcium channel from smooth muscle has a similar size and homologous alpha-subunits to those of the purified skeletal muscle calcium channel.
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