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  • Title: Regioselective synthesis of 1,3,5-trisubstituted pyrazoles from N-alkylated tosylhydrazones and terminal alkynes.
    Author: Kong Y, Tang M, Wang Y.
    Journal: Org Lett; 2014 Jan 17; 16(2):576-9. PubMed ID: 24432814.
    Abstract:
    An efficient synthesis of 1,3,5-trisubstituted pyrazoles from N-alkylated tosylhydrazones and terminal alkynes was developed. The protocol was applied to a wide range of substrates and demonstrated excellent tolerance to a variety of substituents, including both electron-donating and -withdrawing groups. In comparison with the common approaches for substituted pyrazole syntheses, this methodology proceeded with complete regioselectivity, especially, in the cases that R(2) and R(3) are similar substituents.
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