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  • Title: [Decreased alpha fetoprotein in maternal serum in relation to increased alpha fetoprotein in amniotic fluid in a case of fetal trisomy 21 associated with esophageal atresia].
    Author: Gembruch U, Bellmann O, Hansmann M.
    Journal: Geburtshilfe Frauenheilkd; 1987 Aug; 47(8):569-71. PubMed ID: 2443419.
    Abstract:
    A subnormal maternal serum alpha-fetoprotein level associated with elevated alpha-fetoprotein level in amniotic fluid was found in a case of trisomy 21 combined with esophageal atresia in a fetus at 36 + 5 weeks of gestation. The significance of this observation is discussed in view of the possible biologic mechanisms resulting in maternal serum alpha-fetoprotein reduction in cases of fetal autosomal trisomies. The most likely hypotheses seem to be a reduced fetal alpha-fetoprotein production and/or an alteration of the placental regulation of the alpha-fetoprotein transfer from fetal to maternal blood via the placenta.
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