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  • Title: Construction and evaluation of a switch-tuned (13) C - (1) H birdcage radiofrequency coil for imaging the metabolism of hyperpolarized (13) C-enriched compounds.
    Author: Lim H, Thind K, Martinez-Santiesteban FM, Scholl TJ.
    Journal: J Magn Reson Imaging; 2014 Nov; 40(5):1082-90. PubMed ID: 24436187.
    Abstract:
    PURPOSE: To construct a switch-tuned (13) C - (1) H birdcage radiofrequency (RF) coil system capable of metabolic imaging of hyperpolarized (13) C-enriched metabolic probes for co-registration with MRI morphology using protons. MATERIALS AND METHODS: The switch-tuned coil was constructed using PIN diodes for rapid switching of the resonant frequency of the coil. Identical, single-tuned, (1) H and (13) C birdcage RF coils have also been constructed for comparison of imaging performance. A (13) C receive-only surface RF coil has been integrated with the switch-tuned coil for transmit-only, receive-only operation (TORO) to increase local (13) C signal for improved signal-to-noise ratio (SNR). RESULTS: The SNR achieved with the switch-tuned coil in transmit/receive mode was 87% that of the single-tuned (1) H coil. For (13) C imaging, the SNR for the switch-tuned coil was 55% that of the single-tuned (13) C coil. TORO operation of the switch-tuned coil with the surface coil increased SNR for by a factor of 4.2 over transmit/receive operation of the switch-tuned coil alone. CONCLUSION: A surface coil can be integrated with a switch-tuned (13) C - (1) H coil for (13) C TORO operation producing improved SNR. In vivo metabolic imaging of [1-(13) C]pyruvate in a rat model of glioma is demonstrated using TORO operation, which is co-registered with (1) H-imaged anatomy.
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