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  • Title: T-lineage acute lymphoblastic leukemia and parvovirus infection in a child with neurofibromastosis-1.
    Author: Agarwal P, Naseem S, Varma N, Marwaha RK.
    Journal: Indian J Pathol Microbiol; 2013; 56(4):446-8. PubMed ID: 24441245.
    Abstract:
    Neurofibromatosis (NF-1) patients have an increased risk of developing malignancies most commonly rhabdomyosarcomas, optic gliomas, brain tumors and non-lymphocytic leukemias. Acute lymphoblastic leukemia (ALL) has been infrequently reported in association with NF-1. We describe a rare association of NF-1, T-lineage ALL and parvovirus infection in a 12-year-old child. In addition, it is also to emphasize that a high index of suspicion should be kept for parvovirus B19 infection as a cause of bicytopenia/pancytopenia in ALL patients following induction chemotherapy.
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