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  • Title: Shear wave pulse compression for dynamic elastography using phase-sensitive optical coherence tomography.
    Author: Nguyen TM, Song S, Arnal B, Wong EY, Huang Z, Wang RK, O'Donnell M.
    Journal: J Biomed Opt; 2014 Jan; 19(1):16013. PubMed ID: 24441876.
    Abstract:
    Assessing the biomechanical properties of soft tissue provides clinically valuable information to supplement conventional structural imaging. In the previous studies, we introduced a dynamic elastography technique based on phase-sensitive optical coherence tomography (PhS-OCT) to characterize submillimetric structures such as skin layers or ocular tissues. Here, we propose to implement a pulse compression technique for shear wave elastography. We performed shear wave pulse compression in tissue-mimicking phantoms. Using a mechanical actuator to generate broadband frequency-modulated vibrations (1 to 5 kHz), induced displacements were detected at an equivalent frame rate of 47 kHz using a PhS-OCT. The recorded signal was digitally compressed to a broadband pulse. Stiffness maps were then reconstructed from spatially localized estimates of the local shear wave speed. We demonstrate that a simple pulse compression scheme can increase shear wave detection signal-to-noise ratio (>12  dB gain) and reduce artifacts in reconstructing stiffness maps of heterogeneous media.
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