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  • Title: Regulation of sodium influx and sodium, potassium pump activity by a sodium-hydrogen antiport in rat vascular smooth muscle.
    Author: Bobik A, Weissberg PL, Little PJ.
    Journal: Clin Exp Pharmacol Physiol; 1987 Mar; 14(3):191-5. PubMed ID: 2444372.
    Abstract:
    1. The effects of Na-H antiport inhibitors on sodium influx, intracellular pH and Na,K-pump activity were examined in vascular smooth muscle from rats. 2. Amiloride and 5-(N-ethyl-N-isopropyl)amiloride inhibited Na accumulation following inhibition of the Na,K-pump. 3. Inhibition of Na influx was associated with a reduction in basal Na,K-pump activity and intracellular pH. 4. It is concluded that a Na-H antiport system in vascular smooth muscle regulates Na influx rate, contributes to intracellular pH regulation and influences basal levels of Na,K-pump activity.
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