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  • Title: Molecular logic gates on DNA origami nanostructures for microRNA diagnostics.
    Author: Wang D, Fu Y, Yan J, Zhao B, Dai B, Chao J, Liu H, He D, Zhang Y, Fan C, Song S.
    Journal: Anal Chem; 2014 Feb 18; 86(4):1932-6. PubMed ID: 24447268.
    Abstract:
    Molecular computing holds great promise for diagnosis and treatment of diseases at the molecular level; nevertheless, designing molecular logic gates to operate programmably and autonomously for molecular diagnostics still remains challenging. We designed logic gates on DNA Origami for microRNA analysis. As a demonstration, two indicators of heart failure, microRNA-21 and microRNA-195, were selected as the logic inputs. The logic gates contain two main modules: computation module and output module, performing in a single DNA Origami nanostructure. The computation module recognizes disease indicators, while the output module display different nanoscale symbols, "+" (positive) or "-" (negative), depending on the computing results. We demonstrated that the molecular logic gates worked well with single and two input combinations.
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