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  • Title: [Enzyme induction and anticonvulsants].
    Author: Mapelli G.
    Journal: Schweiz Arch Neurol Psychiatr (1985); 1987; 138(4):13-23. PubMed ID: 2445024.
    Abstract:
    Serum gamma-GT-activity was significantly (0.01 greater than P greater than 0.001) elevated in 18 of 30 epileptics receiving carbamazepine (CBZ), i.e. in 60%. The incidence of abnormal gamma-GT-levels in the control group (25 neurotic patients taking minor tranquilizers) was lower (12%). The possible relationships between the enzyme induction or chronic hepatic toxicity and the elevation of serum gamma-GT-activity in epileptics taking CBZ are discussed.
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