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  • Title: [Sensitivity of antineoplastic agents in squamous cell carcinoma of the uterine cervix xenografted into nude mice].
    Author: Kawabata M, Hosokawa H, Katoh K, Izumi R.
    Journal: Gan To Kagaku Ryoho; 1987 Nov; 14(11):3058-63. PubMed ID: 2445295.
    Abstract:
    Antitumor efficacies of five antineoplastic agents, cisplatin, mitomycin, doxorubicin, 5-fluorouracil and bleomycin were tested against the human carcinoma of the uterine cervix xenografted into nude mice in order to search for effective combination chemotherapy. Antineoplastic agent was administered i.p. 6 times once a week to nude mice with tumor growing to 8-10 mm in diameter. The effect in each group was evaluated by Battelle Columbus Laboratories' method, measuring at 6th week the tumor growth rate in the treatment group (Tn/T0) and in the control group (Cn/C0) where the comparative tumor growth ratio (Tn/T0/Cn/C0) was taken as the index. As the result, the response rates of cisplatin and mitomycin on the tumor growth were high as 83.3% and 66.7% respectively. It is concluded that combination chemotherapy including cisplatin and mitomycin is recommendable for the treatment of squamous cell carcinoma of the uterine cervix.
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