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  • Title: The lipid composition of porcine epidermis and oral epithelium.
    Author: Squier CA, Cox PS, Wertz PW, Downing DT.
    Journal: Arch Oral Biol; 1986; 31(11):741-7. PubMed ID: 2445322.
    Abstract:
    The permeability barrier of mammalian skin has been analysed in terms of its lipid composition whereas that of the oral mucosa is uncharacterized. As there are differences in permeability between different regions of the oral mucosa, and between the oral mucosa and skin, there may be corresponding differences in the nature of the barrier layer. Lipids were identified by thin-layer chromatography after solvent extraction of separated epithelium; their localization was determined in histological sections using standard histochemical stains. Keratinized oral epithelium and epidermis showed a similar pattern of lipid distribution, the majority of neutral lipids being ceramides, localized around the cells of the stratum corneum. The non-keratinized epithelium contained few neutral lipids but polar lipids, particularly cholesterol sulphate and glucosylceramides, were clearly evident. Histochemical staining suggested that these were localized in intercellular regions throughout the epithelium. The differences in the types and distribution of lipids accord well with known permeability differences, which show that keratinized oral epithelium and epidermis have a similar impermeability to water and that non-keratinized regions have greater permeability.
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