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  • Title: [Localization of the antigenic determinants in carcinoembryonic antigen: the role of the carbohydrate component].
    Author: Pavlenko AF, Kurika AV, Chikalovets IV, Korzhikov IA, Glazunov VP.
    Journal: Bioorg Khim; 1987 Jun; 13(6):814-7. PubMed ID: 2445351.
    Abstract:
    The majority of topographic antigenic determinants of the carcinoembryonic antigen (CEA) representing a glycoprotein were shown to contain sugar residues of the CEA carbohydrate chains. Periodate oxidation of CEA followed by reduction afforded a corresponding CEA derivate (CEA-POR), which retained 3% antigenic activity of CEA. In secondary and tertiary structures CEA-POR was proved to be close to CEA pre heated to 80 degrees C. Formation of borate complexes with sugar residues of CEA decreased the CEA antigenic activity to 5% while a but did not affect the spatial structure of its protein core.
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