These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Tetraoxanes as antimalarials: harnessing the endoperoxide.
    Author: Fisher LC, Blackie MA.
    Journal: Mini Rev Med Chem; 2014 Feb; 14(2):123-35. PubMed ID: 24456270.
    Abstract:
    With the emergence of resistance to artemesinin, the need for new antimalarial compounds is pressing. Several research groups have made significant contributions to the exploration of the use of 1,2,4,5-tetraoxanes and 1,2,4- trioxanes as synthetic analogues of artemesinin. This short review highlights the recent developments in this field detailing both biological results and useful synthetic methodology. In addition, the current understanding of the mode of action of this class of compounds has been described.
    [Abstract] [Full Text] [Related] [New Search]