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  • Title: [Hemorheologic, micro- and macrocirculatory effects of hypervolemic infusions of middle molecular weight hydroxyethyl starch (10%, 200,000/0.62) in healthy probands].
    Author: Scheffler P, Jung F, Mrowietz C, Waldhausen P, Leipnitz G, Häuser B.
    Journal: Infusionsther Klin Ernahr; 1987 Oct; 14(5):233-8. PubMed ID: 2445681.
    Abstract:
    During an open clinical trial the influence of hypervolemic hemodilution (Infusion of 500 cc Elohäst within 1 h) on macrocirculation, microcirculation and blood fluidity of healthy volunteers was investigated. Blood pressure and heart rate remained constant during the infusion period and later on. The decline in hematocrit after 6 h was four points, plasma viscosity and erythrocyte aggregation, however, increased significantly. Three hours after completion of the infusion a significantly elevated blood flow in the common carotid artery could be assessed with a return to approximately normal values after 6 h. The improvement of the microcirculatory flow took a longer period of time. After 6 h a significantly increased erythrocyte velocity in the nailfold capillaries along with a significant augmentation of transcutaneously measured partial oxygen pressure could be stated.
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