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  • Title: A new nasal decongestant, A-57219: a comparison with oxymetazoline.
    Author: DeBernardis JF, Winn M, Kerkman DJ, Kyncl JJ, Buckner S, Horrom B.
    Journal: J Pharm Pharmacol; 1987 Sep; 39(9):760-3. PubMed ID: 2445950.
    Abstract:
    2-(4-Amino-3,5-dichlorobenzyl)imidazoline hydrochloride (A-57219), has alpha 1-agonist/alpha 2-antagonist activity and was more effective and long-acting than oxymetazoline on canine nasal mucosa, in-vitro and in-vivo. Upon intranasal administration to dogs, the compound was devoid of systemic effects up to a concentration 1000 times that needed for local decongestant effect (1.65 micrograms, atomized from a 1 microgram mL-1 solution) suggesting limited mucosal absorption. After nasal administration to rats for 15 days at a concentration 1000 times greater than that required for nasal decongestion, no mucosal tissue toxicity or systemic effects were seen.
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