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  • Title: Severe ischemic bowel necrosis caused by terlipressin during treatment of hepatorenal syndrome.
    Author: Kim HR, Lee YS, Yim HJ, Lee HJ, Ryu JY, Lee HJ, Yoon EL, Lee SJ, Hyun JJ, Jung SW, Koo JS, Choung RS, Lee SW, Choi JH.
    Journal: Clin Mol Hepatol; 2013 Dec; 19(4):417-20. PubMed ID: 24459647.
    Abstract:
    Terlipressin is a vasopressin analogue that is widely used in the treatment of hepatorenal syndrome or variceal bleeding. Because it acts mainly on splanchnic vessels, terlipressin has a lower incidence of severe ischemic complications than does vasopressin. However, it can still lead to serious complications such as myocardial infarction, skin necrosis, or bowel ischemia. Herein we report a case of severe ischemic bowel necrosis in a 46-year-old cirrhotic patient treated with terlipressin. Although the patient received bowel resection, death occurred due to ongoing hypotension and metabolic acidosis. Attention should be paid to patients complaining of abdominal pain during treatment with terlipressin.
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